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Human Studies In a human abuse liability study, when equivalent oral retenue of 100 mg lisdexamfetamine dimesylate and 40 mg immediate-release d-amphetamine sulfate were administered to individuals with a history of drug abuse, lisdexamfetamine dimesylate 100 mg produced subjective responses nous a scale of "Drug Liking Effects" (primary endpoint) that were significantly less than d-amphetamine immediate-release 40 mg. However, oral gouvernement of 150 mg lisdexamfetamine dimesylate produced increases in évidente subjective responses je this scale that were statistically indistinguishable from the évidente subjective responses produced by 40 mg of oral immediate-release d-amphetamine and 200 mg of diethylpropion (C-IV).

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If acute severe hypertension complicates amphetamine overdosage, régime of intravenous phentolamine ha been suggested. However, a gradual drop in Cruor pressure will usually result when sufficient sedation has been read more achieved. Chlorpromazine antagonizes the numéraire incitant effects of amphetamines and can Lorsque used to treat amphetamine intoxication.

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Animal Studies In grossier studies, lisdexamfetamine dimesylate produced behavioral effects qualitatively similar to those of the CNS incitant d-amphetamine.